Students construct paper recombinant plasmids to simulate the methods genetic engineers use to create modified bacteria. They learn what role enzymes, DNA and genes play in the modification of organisms. For the particular model they work on, they isolate a mammal insulin gene and combine it with a bacteria's gene sequence (plasmid DNA) for production of the protein insulin.

Learn about DNA. Deoxyribonucleic acid is the blueprint for all living things, but it is so small we can’t usually see it. The role of DNA is to provide our cells information on building proteins; these proteins lead to our individual traits such as eye color, height, dimples, and so much more. The structure of DNA is a double helix and we can model this structure at home. This model is based on the work of Rosalind Franklin, a British Chemist who created an X-ray photograph that provided evidence of the double-helix structure of DNA molecules. We can also extract DNA from a living thing, such as a strawberry, at home. The components of this DNA are so small that it does not look like our model; however, with technology scientists can both see the structure and manipulate the structure to change proteins in organisms. The key concepts and terms explored in this episode include DNA, nucleotides, genes, and genetically modified organisms (GMO's).

Students learn how engineers apply their understanding of DNA to manipulate specific genes to produce desired traits, and how engineers have used this practice to address current problems facing humanity. They learn what genetic engineering means and examples of its applications, as well as moral and ethical problems related to its implementation. Students fill out a flow chart to list the methods to modify genes to create GMOs and example applications of bacteria, plant and animal GMOs.

Students read about and explain the process of transgenic manipulation to produce crops resistant to herbicides and pests. Afterwards students evaluate the pros and cons. Next, students read various pro/neutral/con articles about genetically modified foods and evaluate the perspective of the author. Finally, students use evidence from the reading to write a CER stating their opinion on GMOs.