Students conduct their own research to discover and understand the methods designed by engineers and used by scientists to analyze or validate the molecular structure of DNA, proteins and enzymes, as well as basic information about gel electrophoresis and DNA identification. In this computer-based activity, students investigate particular molecular imaging technologies, such as x-ray, atomic force microscopy, transmission electron microscopy, and create short PowerPoint presentations that address key points. The presentations include their own explanations of the difference between molecular imaging and gel electrophoresis.

Students will participate in a 5E lesson. To ENGAGE, students will connect their understanding of the characteristics of life to the fundamental molecule of life: DNA. To EXPLORE, students will extract DNA from fruit in a hands on (or video of a) lab, and then, students will act as Watson and Crick and use clues to discover the structure of DNA. In the EXPLAIN section, students will use slides to fill out guided notes on the structure of DNA and RNA. To ELABORATE on their understanding of DNA, students can participate in the CRISPR-Cas9 interactive and the Regulation of the Lactase Gene click and learn. Formative evaluations of students's ability to model DNA include (1) using an online interactive, (2) using their bodies as a class, and (3) using a cut and paste model. Finally, the summative EVALUATE is a DNA Model FlipGrid in which students use various materials to construct and explain the structure of DNA.

This lesson is designed for a high school biology class, as it is dependent on students having some prior knowledge of the structure of DNA. It reviews/teaches the key features of DNA structure by allowing students to use the engineering design process to create their own DNA models, compare/contrast provided models, and then edit/assess their own designs.